Selective Effects of a Morphine Conjugate Vaccine on Heroin and Metabolite Distribution and Heroin-Induced Behaviors in Rats

Morphine conjugate vaccines have effectively reduced behavioral effects of heroin in rodents and primates. To better understand how these effects are mediated, heroin and metabolite distribution studies were performed in rats in the presence and absence of vaccination. In non-vaccinated rats 6-monoa...

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Bibliographic Details
Main Authors: Raleigh, M.D., Pravetoni, M., Harris, A.C., Birnbaum, A.K., Pentel, P.R.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2013
Subjects:
Drug Discovery and Translational Medicine
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558830/
https://ncbi.nlm.nih.gov/pubmed/23220743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.201194
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