An Oxycodone Conjugate Vaccine Elicits Drug-Specific Antibodies that Reduce Oxycodone Distribution to Brain and Hot-Plate Analgesia

Opioid conjugate vaccines have shown promise in attenuating the behavioral effects of heroin or morphine in animals. The goal of this study was to extend this approach to oxycodone (OXY), a commonly abused prescription opioid. Haptens were generated by adding tetraglycine (Gly)(4) or hemisuccinate (...

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Библиографические подробности
Главные авторы: Pravetoni, M., Le Naour, M., Harmon, T. M., Tucker, A. M., Portoghese, P. S., Pentel, P. R.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2012
Предметы:
Drug Discovery and Translational Medicine
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310692/
https://ncbi.nlm.nih.gov/pubmed/22262924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.189506
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