The Selective Syk Inhibitor P505-15 (PRT062607) Inhibits B Cell Signaling and Function In Vitro and In Vivo and Augments the Activity of Fludarabine in Chronic Lymphocytic Leukemia

B-cell receptor (BCR) associated kinases including spleen tyrosine kinase (SYK) contribute to the pathogenesis of B-cell malignancies. SYK is persistently phosphorylated in a subset of non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL), and SYK inhibition results in abrogation of down...

Full description

Saved in:
Bibliographic Details
Main Authors: Spurgeon, Stephen E., Coffey, Greg, Fletcher, Luke B., Burke, Russell, Tyner, Jeffrey W., Druker, Brian J., Betz, Andreas, DeGuzman, Francis, Pak, Yvonne, Baker, Dale, Pandey, Anjali, Hollenbach, Stanley J., Sinha, Uma, Loriaux, Marc M.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2013
Subjects:
Chemotherapy, Antibiotics, and Gene Therapy
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558816/
https://ncbi.nlm.nih.gov/pubmed/23220742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.200832
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items