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Revisiting the putative TCR Cα dimerization model through structural analysis
Despite major advances in T cell receptor (TCR) biology and structure, how peptide–MHC complex (pMHC) ligands trigger αβ TCR activation remains unresolved. Two views exist. One model postulates that monomeric TCR–pMHC ligation events are sufficient while a second proposes that TCR–TCR dimerization i...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3558723/ https://ncbi.nlm.nih.gov/pubmed/23386853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2013.00016 |
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