Mutations Causing Childhood Ataxia with Central Nervous System Hypomyelination Reduce Eukaryotic Initiation Factor 2B Complex Formation and Activity

Childhood ataxia with central nervous system hypomyelination (CACH), or vanishing white matter leukoencephalopathy (VWM), is a fatal brain disorder caused by mutations in eukaryotic initiation factor 2B (eIF2B). eIF2B is essential for protein synthesis and regulates translation in response to cellul...

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Bibliographische Detailangaben
Hauptverfasser: Richardson, Jonathan P., Mohammad, Sarah S., Pavitt, Graham D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC355856/
https://ncbi.nlm.nih.gov/pubmed/14993275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.6.2352-2363.2004
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