Localized DNA Demethylation at Recombination Intermediates during Immunoglobulin Heavy Chain Gene Assembly

Multiple epigenetic marks have been proposed to contribute to the regulation of antigen receptor gene assembly via V(D)J recombination. Here we provide a comprehensive view of DNA methylation at the immunoglobulin heavy chain (IgH) gene locus prior to and during V(D)J recombination. DNA methylation...

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Autors principals: Selimyan, Roza, Gerstein, Rachel M., Ivanova, Irina, Precht, Patricia, Subrahmanyam, Ramesh, Perlot, Thomas, Alt, Frederick W., Sen, Ranjan
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558432/
https://ncbi.nlm.nih.gov/pubmed/23382652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001475
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