A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation

A tissue-specific transcriptional enhancer, Eμ, has been implicated in developmentally regulated recombination and transcription of the immunoglobulin heavy chain (IgH) gene locus. We demonstrate that deleting 220 nucleotides that constitute the core Eμ results in partially active locus, characteriz...

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Bibliographic Details
Main Authors: Chakraborty, Tirtha, Perlot, Thomas, Subrahmanyam, Ramesh, Jani, Anant, Goff, Peter H., Zhang, Yu, Ivanova, Irina, Alt, Frederick W., Sen, Ranjan
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715034/
https://ncbi.nlm.nih.gov/pubmed/19414554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20081621
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