A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation

A tissue-specific transcriptional enhancer, Eμ, has been implicated in developmentally regulated recombination and transcription of the immunoglobulin heavy chain (IgH) gene locus. We demonstrate that deleting 220 nucleotides that constitute the core Eμ results in partially active locus, characteriz...

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Xehetasun bibliografikoak
Egile Nagusiak: Chakraborty, Tirtha, Perlot, Thomas, Subrahmanyam, Ramesh, Jani, Anant, Goff, Peter H., Zhang, Yu, Ivanova, Irina, Alt, Frederick W., Sen, Ranjan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2009
Gaiak:
Brief Definitive Report
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715034/
https://ncbi.nlm.nih.gov/pubmed/19414554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20081621
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