Proteomic analysis of ERK1/2-mediated human sickle red blood cell membrane protein phosphorylation

BACKGROUND: In sickle cell disease (SCD), the mitogen-activated protein kinase (MAPK) ERK1/2 is constitutively active and can be inducible by agonist-stimulation only in sickle but not in normal human red blood cells (RBCs). ERK1/2 is involved in activation of ICAM-4-mediated sickle RBC adhesion to...

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Bibliografske podrobnosti
Main Authors: Soderblom, Erik J, Thompson, J Will, Schwartz, Evan A, Chiou, Edward, Dubois, Laura G, Moseley, M Arthur, Zennadi, Rahima
Format: Artigo
Jezik:Inglês
Izdano: Springer 2013
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558407/
https://ncbi.nlm.nih.gov/pubmed/23286773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1559-0275-10-1
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