De novo assembly of bacterial genomes from single cells

Whole genome amplification by the multiple displacement amplification (MDA) method allows sequencing of genomes from single cells of bacteria that cannot be cultured. However, genome assembly is challenging because of highly non-uniform read coverage generated by MDA. We describe an improved assembl...

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Bibliographic Details
Main Authors: Chitsaz, Hamidreza, Yee-Greenbaum, Joyclyn L., Tesler, Glenn, Lombardo, Mary-Jane, Dupont, Christopher L., Badger, Jonathan H., Novotny, Mark, Rusch, Douglas B., Fraser, Louise J., Gormley, Niall A., Schulz-Trieglaff, Ole, Smith, Geoffrey P., Evers, Dirk J., Pevzner, Pavel A., Lasken, Roger S.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558281/
https://ncbi.nlm.nih.gov/pubmed/21926975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1966
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