De novo assembly of bacterial genomes from single cells

Whole genome amplification by the multiple displacement amplification (MDA) method allows sequencing of genomes from single cells of bacteria that cannot be cultured. However, genome assembly is challenging because of highly non-uniform read coverage generated by MDA. We describe an improved assembl...

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Main Authors: Chitsaz, Hamidreza, Yee-Greenbaum, Joyclyn L., Tesler, Glenn, Lombardo, Mary-Jane, Dupont, Christopher L., Badger, Jonathan H., Novotny, Mark, Rusch, Douglas B., Fraser, Louise J., Gormley, Niall A., Schulz-Trieglaff, Ole, Smith, Geoffrey P., Evers, Dirk J., Pevzner, Pavel A., Lasken, Roger S.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558281/
https://ncbi.nlm.nih.gov/pubmed/21926975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1966
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