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Plasmin-dependent proteolysis of Tissue Factor Pathway Inhibitor in a mouse model of endotoxemia

BACKGROUND: Development of a procoagulant state in sepsis, due to aberrant expression of tissue factor (TF) and sharp decrease of its major inhibitor tissue factor pathway inhibitor (TFPI), could lead to microthrombotic organ failure. The mechanism for the decline of TFPI activity in the lung could...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lupu, Cristina, Herlea, Oana, Tang, Haiwang, Lijnen, Roger H., Lupu, Florea
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557666/
https://ncbi.nlm.nih.gov/pubmed/23106863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.12044
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