Plasmin-dependent proteolysis of Tissue Factor Pathway Inhibitor in a mouse model of endotoxemia

BACKGROUND: Development of a procoagulant state in sepsis, due to aberrant expression of tissue factor (TF) and sharp decrease of its major inhibitor tissue factor pathway inhibitor (TFPI), could lead to microthrombotic organ failure. The mechanism for the decline of TFPI activity in the lung could...

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Main Authors: Lupu, Cristina, Herlea, Oana, Tang, Haiwang, Lijnen, Roger H., Lupu, Florea
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557666/
https://ncbi.nlm.nih.gov/pubmed/23106863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.12044
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