Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein

Due to the emergence of drug-resistant strains and the cumulative toxicities associated with current therapies, demand remains for new inhibitors of HIV-1 replication. The HIV-1 matrix (MA) protein is an essential viral component with established roles in the assembly of the virus. Using virtual and...

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Main Authors: Zentner, Isaac, Sierra, Luz-Jeannette, Maciunas, Lina, Vinnik, Andrei, Fedichev, Peter, Mankowski, Marie K., Ptak, Roger G., Martín-García, Julio, Cocklin, Simon
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557583/
https://ncbi.nlm.nih.gov/pubmed/23305922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.11.041
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