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Discovery and optimization of novel small-molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacement

With the emergence of drug-resistant strains and the cumulative toxicities associated with current therapies, demand remains for new inhibitors of HIV-1 replication. The inhibition of HIV-1 entry is an attractive, yet underexploited therapeutic approach with implications for salvage and preexposure...

詳細記述

保存先:
書誌詳細
出版年:Bioorg Med Chem Lett
主要な著者: Tuyishime, Marina, Danish, Matt, Princiotto, Amy, Mankowski, Marie K., Lawrence, Rae, Lombart, Henry-Georges, Esikov, Kirill, Berniac, Joel, Liang, Kuang, Jingjing, Ji, Ptak, Roger G., Madani, Navid, Cocklin, Simon
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355043/
https://ncbi.nlm.nih.gov/pubmed/25454268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.10.027
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