Nitric oxide-dependent CYP2B degradation is potentiated by a cytokine-regulated pathway and utilizes the immunoproteasome subunit LMP2

CYP2B proteins in rat hepatocytes undergo NO-dependent proteolytic degradation, but the mechanisms and the reasons for the specificity towards only certain P450 (cytochrome P450) enzymes are yet unknown. In the present study we found that down-regulation of CYP2B proteins by the NO donor NOC-18 is a...

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Bibliographic Details
Main Authors: Sun, Haiyan, Lee, Choon-myung, Tripathi, Shweta, Kim, Kyung-Bo, Morgan, Edward T.
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557507/
https://ncbi.nlm.nih.gov/pubmed/22612225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20120820
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