Signaling dynamics of palmitate-induced ER stress responses mediated by ATF4 in HepG2 cells

BACKGROUND: Palmitic acid, the most common saturated free fatty acid, has been implicated in ER (endoplasmic reticulum) stress-mediated apoptosis. This lipoapotosis is dependent, in part, on the upregulation of the activating transcription factor-4 (ATF4). To better understand the mechanisms by whic...

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Bibliographic Details
Main Authors: Cho, Hyunju, Wu, Ming, Zhang, Linxia, Thompson, Ryan, Nath, Aritro, Chan, Christina
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557202/
https://ncbi.nlm.nih.gov/pubmed/23339444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-7-9
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