LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1

Fibrosis of vital organs is a major public health problem with limited therapeutic options. Mesenchymal cells including microvascular mural cells (pericytes) are major progenitors of scar-forming myofibroblasts in kidney and other organs. Here we show pericytes in healthy kidneys have active WNT/β-c...

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Hauptverfasser: Ren, Shuyu, Johnson, Bryce G., Kida, Yujiro, Ip, Colin, Davidson, Kathryn C., Lin, Shuei-Liong, Kobayashi, Akio, Lang, Richard A., Hadjantonakis, Anna-Katerina, Moon, Randall T., Duffield, Jeremy S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557093/
https://ncbi.nlm.nih.gov/pubmed/23302695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211179110
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