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Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway

Alnumycin A is an exceptional aromatic polyketide that contains a carbohydrate-like 4′-hydroxy-5′-hydroxymethyl-2′,7′-dioxane moiety attached to the aglycone via a carbon−carbon bond. Recently, we have identified the D-ribose-5-phosphate origin of the dioxane unit and demonstrated that AlnA and AlnB...

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Detalhes bibliográficos
Main Authors: Oja, Terhi, Niiranen, Laila, Sandalova, Tatyana, Klika, Karel D., Niemi, Jarmo, Mäntsälä, Pekka, Schneider, Gunter, Metsä-Ketelä, Mikko
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557020/
https://ncbi.nlm.nih.gov/pubmed/23297194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207407110
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