Blockade but Not Overexpression of the Junctional Adhesion Molecule C Influences Virus-Induced Type 1 Diabetes in Mice

Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing beta-cells in the pancreas. Recruitment of inflammatory cells is prerequisite to beta-cell-injury. The junctional adhesion molecule (JAM) family proteins JAM-B and JAM–C are involved in polarized leukocyte transendoth...

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Main Authors: Christen, Selina, Coppieters, Ken, Rose, Kerstin, Holdener, Martin, Bayer, Monika, Pfeilschifter, Josef M., Hintermann, Edith, von Herrath, Matthias G., Aurrand-Lions, Michel, Imhof, Beat A., Christen, Urs
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3556033/
https://ncbi.nlm.nih.gov/pubmed/23372751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054675
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