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Cytochrome P450 2D6 as a Model Antigen

Cytochrome P450 2D6 (CYP2D6) has been identified as the major autoantigen in type 2 autoimmune hepatitis (AIH). However, because of a lack of appropriate animal models, the etiology of AIH is still poorly understood. We generated a mouse model for AIH using the human CYP2D6 as a triggering molecule...

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Detalhes bibliográficos
Main Authors: Christen, Urs, Holdener, Martin, Hintermann, Edith
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883835/
https://ncbi.nlm.nih.gov/pubmed/20460894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000282068
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