Generation of Biologically Active Multi-Sialylated Recombinant Human EPOFc in Plants

Hyperglycosylated proteins are more stable, show increased serum half-life and less sensitivity to proteolysis compared to non-sialylated forms. This applies particularly to recombinant human erythropoietin (rhEPO). Recent progress in N-glycoengineering of non-mammalian expression hosts resulted in...

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Main Authors: Castilho, Alexandra, Neumann, Laura, Gattinger, Pia, Strasser, Richard, Vorauer-Uhl, Karola, Sterovsky, Thomas, Altmann, Friedrich, Steinkellner, Herta
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3555983/
https://ncbi.nlm.nih.gov/pubmed/23372778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054836
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