The Bile Acid Sensor FXR Is Required for Immune-Regulatory Activities of TLR-9 in Intestinal Inflammation

BACKGROUND: Toll like receptors (TLRs) sense the intestinal microbiota and regulate the innate immune response. A dysregulation of TLRs function participates into intestinal inflammation. Farnesoid X Receptor (FXR) is a nuclear receptor and bile acid sensor highly expressed in entero-hepatic tissues...

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Autores principales: Renga, Barbara, Mencarelli, Andrea, Cipriani, Sabrina, D'Amore, Claudio, Carino, Adriana, Bruno, Angela, Francisci, Daniela, Zampella, Angela, Distrutti, Eleonora, Fiorucci, Stefano
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3555871/
https://ncbi.nlm.nih.gov/pubmed/23372731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054472
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