ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression

Sepsis, sepsis-induced hyperinflammation and subsequent sepsis-associated immunosuppression (SAIS) are important causes of death. Here we show in humans that the loss of the major reactive oxygen species (ROS) scavenger, glutathione (GSH), during SAIS directly correlates with an increase in the expr...

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Main Authors: Hoetzenecker, Wolfram, Echtenacher, Bernd, Guenova, Emmanuella, Hoetzenecker, Konrad, Woelbing, Florian, Brück, Jürgen, Teske, Anna, Valtcheva, Nadejda, Fuchs, Kerstin, Kneilling, Manfred, Park, Ji-Hyeon, Kim, Kyu-Han, Kim, Kyu-Won, Hoffmann, Petra, Krenn, Claus, Hai, Tsonwin, Ghoreschi, Kamran, Biedermann, Tilo, Röcken, Martin
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3555699/
https://ncbi.nlm.nih.gov/pubmed/22179317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2557
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