Contribution of BCR-ABL kinase domain mutations to imatinib mesylate resistance in Philadelphia chromosome positive Malaysian chronic myeloid leukemia patients

Development of resistance to imatinib mesylate (IM) in chronic myeloid leukemia (CML) patients is mediated by different mechanisms that can be classified as BCR-ABL dependent or BCR-ABL independent pathways. BCR-ABL dependent mechanisms are most frequently associated with point mutations in tyrosine...

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Main Authors: Elias, Marjanu Hikmah, Baba, Abdul Aziz, Husin, Azlan, Abdullah, Abu Dzarr, Hassan, Rosline, Sim, Goh Ai, Wahid, S. Fadilah Abdul, Ankathil, Ravindran
Format: Artigo
Jezik:Inglês
Izdano: PAGEPress Publications 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3555211/
https://ncbi.nlm.nih.gov/pubmed/23355941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4081/hr.2012.e23
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