HOXA4 Gene Promoter Hypermethylation as an Epigenetic Mechanism Mediating Resistance to Imatinib Mesylate in Chronic Myeloid Leukemia Patients

Development of resistance to imatinib mesylate (IM) in chronic myeloid leukemia (CML) patients has emerged as a significant clinical problem. The observation that increased epigenetic silencing of potential tumor suppressor genes correlates with disease progression in some CML patients treated with...

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Bibliografiske detaljer
Main Authors: Elias, Marjanu Hikmah, Baba, Abdul Aziz, Husin, Azlan, Sulong, Sarina, Hassan, Rosline, Sim, Goh Ai, Abdul Wahid, S. Fadilah, Ankathil, Ravindran
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591123/
https://ncbi.nlm.nih.gov/pubmed/23484077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/129715
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