HOXA4 Gene Promoter Hypermethylation as an Epigenetic Mechanism Mediating Resistance to Imatinib Mesylate in Chronic Myeloid Leukemia Patients

Development of resistance to imatinib mesylate (IM) in chronic myeloid leukemia (CML) patients has emerged as a significant clinical problem. The observation that increased epigenetic silencing of potential tumor suppressor genes correlates with disease progression in some CML patients treated with...

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Main Authors: Elias, Marjanu Hikmah, Baba, Abdul Aziz, Husin, Azlan, Sulong, Sarina, Hassan, Rosline, Sim, Goh Ai, Abdul Wahid, S. Fadilah, Ankathil, Ravindran
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591123/
https://ncbi.nlm.nih.gov/pubmed/23484077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/129715
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