HOXA4 Gene Promoter Hypermethylation as an Epigenetic Mechanism Mediating Resistance to Imatinib Mesylate in Chronic Myeloid Leukemia Patients

Development of resistance to imatinib mesylate (IM) in chronic myeloid leukemia (CML) patients has emerged as a significant clinical problem. The observation that increased epigenetic silencing of potential tumor suppressor genes correlates with disease progression in some CML patients treated with...

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Autors principals: Elias, Marjanu Hikmah, Baba, Abdul Aziz, Husin, Azlan, Sulong, Sarina, Hassan, Rosline, Sim, Goh Ai, Abdul Wahid, S. Fadilah, Ankathil, Ravindran
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591123/
https://ncbi.nlm.nih.gov/pubmed/23484077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/129715
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