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Efficient production of adenovirus vector lacking genes of virus-associated RNAs that disturb cellular RNAi machinery
First-generation adenovirus vectors (FG AdVs) are widely used in basic studies and gene therapy. However, virus-associated (VA) RNAs that act as small-interference RNAs are indeed transcribed from the vector genome. These VA RNAs can trigger the innate immune response. Moreover, VA RNAs are processe...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3555086/ https://ncbi.nlm.nih.gov/pubmed/23355950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01136 |
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