Adenovirus vectors lacking virus-associated RNA expression enhance shRNA activity to suppress hepatitis C virus replication

First-generation adenovirus vectors (FG AdVs) expressing short-hairpin RNA (shRNA) effectively downregulate the expressions of target genes. However, this vector, in fact, expresses not only the transgene product, but also virus-associated RNAs (VA RNAs) that disturb cellular RNAi machinery. We have...

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Hlavní autoři: Pei, Zheng, Shi, Guoli, Kondo, Saki, Ito, Masahiko, Maekawa, Aya, Suzuki, Mariko, Saito, Izumu, Suzuki, Tetsuro, Kanegae, Yumi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868971/
https://ncbi.nlm.nih.gov/pubmed/24356586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03575
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