The Role of γ-Secretase Activating Protein (GSAP) and Imatinib in the Regulation of γ-Secretase Activity and Amyloid-β Generation

γ-Secretase is a large enzyme complex comprising presenilin, nicastrin, presenilin enhancer 2, and anterior pharynx-defective 1 that mediates the intramembrane proteolysis of a large number of proteins including amyloid precursor protein and Notch. Recently, a novel γ-secretase activating protein (G...

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Hlavní autoři: Hussain, Ishrut, Fabrègue, Julien, Anderes, Laurence, Ousson, Solenne, Borlat, Frédéric, Eligert, Valérie, Berger, Sébastien, Dimitrov, Mitko, Alattia, Jean-René, Fraering, Patrick C., Beher, Dirk
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554920/
https://ncbi.nlm.nih.gov/pubmed/23209290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.370924
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