Phosphatase and Tensin Homolog (PTEN)-induced Putative Kinase 1 (PINK1)-dependent Ubiquitination of Endogenous Parkin Attenuates Mitophagy: STUDY IN HUMAN PRIMARY FIBROBLASTS AND INDUCED PLURIPOTENT STEM CELL-DERIVED NEURONS

Mutations in the E3 ubiquitin ligase Parkin and the mitochondrial PTEN-induced putative kinase 1 (PINK1) have been identified to cause autosomal recessive forms of familial Parkinson disease, with PINK1 functioning upstream of Parkin in a pathway important for the maintenance of mitochondrial functi...

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Autors principals: Rakovic, Aleksandar, Shurkewitsch, Katharina, Seibler, Philip, Grünewald, Anne, Zanon, Alessandra, Hagenah, Johann, Krainc, Dimitri, Klein, Christine
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Neurobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554895/
https://ncbi.nlm.nih.gov/pubmed/23212910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.391680
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