Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells

Genetic Parkinson disease (PD) has been associated with mutations in PINK1, a gene encoding a mitochondrial kinase implicated in the regulation of mitochondrial degradation. While the studies so far examined PINK1 function in non-neuronal systems or through PINK1 knockdown approaches, there is an im...

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Detalhes bibliográficos
Main Authors: Seibler, Philip, Graziotto, John, Jeong, Hyun, Simunovic, Filip, Klein, Christine, Krainc, Dimitri
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091622/
https://ncbi.nlm.nih.gov/pubmed/21508222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4441-10.2011
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