Changes In Bone Sclerostin Levels In Mice After Ovariectomy Vary Independently Of Changes In Serum Sclerostin Levels

We examined the effects that ovariectomy had on sclerostin mRNA and protein levels in the bones of 8-week-old mice that were either sham-operated (SHAM) or ovariectomized (OVX) and then sacrificed 3 or 6 wks. later. In this model bone loss occurred between 3 and 5 wks. Post-surgery. In calvaria OVX...

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Bibliographic Details
Main Authors: Jastrzebski, Sandra, Kalinowski, Judith, Stolina, Marina, Mirza, Faryal, Torreggiani, Elena, Kalajzic, Ivo, Won, Hee Yeon, Lee, Sun-Kyeong, Lorenzo, Joseph
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554870/
https://ncbi.nlm.nih.gov/pubmed/23044658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.1773
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