FLT3 Mutations in Early T-Cell Precursor ALL Characterize a Stem Cell Like Leukemia and Imply the Clinical Use of Tyrosine Kinase Inhibitors

Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) has been identified as high-risk subgroup of acute T-lymphoblastic leukemia (T-ALL) with a high rate of FLT3-mutations in adults. To unravel the underlying pathomechanisms and the clinical course we assessed molecular alterations and clin...

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Autors principals: Neumann, Martin, Coskun, Ebru, Fransecky, Lars, Mochmann, Liliana H., Bartram, Isabelle, Farhadi Sartangi, Nasrin, Heesch, Sandra, Gökbuget, Nicola, Schwartz, Stefan, Brandts, Christian, Schlee, Cornelia, Haas, Rainer, Dührsen, Ulrich, Griesshammer, Martin, Döhner, Hartmut, Ehninger, Gerhard, Burmeister, Thomas, Blau, Olga, Thiel, Eckhard, Hoelzer, Dieter, Hofmann, Wolf-Karsten, Baldus, Claudia D.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554732/
https://ncbi.nlm.nih.gov/pubmed/23359050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053190
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