FLT3 Mutations in Early T-Cell Precursor ALL Characterize a Stem Cell Like Leukemia and Imply the Clinical Use of Tyrosine Kinase Inhibitors

Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) has been identified as high-risk subgroup of acute T-lymphoblastic leukemia (T-ALL) with a high rate of FLT3-mutations in adults. To unravel the underlying pathomechanisms and the clinical course we assessed molecular alterations and clin...

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Main Authors: Neumann, Martin, Coskun, Ebru, Fransecky, Lars, Mochmann, Liliana H., Bartram, Isabelle, Farhadi Sartangi, Nasrin, Heesch, Sandra, Gökbuget, Nicola, Schwartz, Stefan, Brandts, Christian, Schlee, Cornelia, Haas, Rainer, Dührsen, Ulrich, Griesshammer, Martin, Döhner, Hartmut, Ehninger, Gerhard, Burmeister, Thomas, Blau, Olga, Thiel, Eckhard, Hoelzer, Dieter, Hofmann, Wolf-Karsten, Baldus, Claudia D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554732/
https://ncbi.nlm.nih.gov/pubmed/23359050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053190
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