Pancreatic Tumors and Immature Immunosuppressive Myeloid Cells in Blood and Spleen: Role of Inhibitory Co-Stimulatory Molecules PDL1 and CTLA4. An In Vivo and In Vitro Study

BACKGROUND: Blood and spleen expansion of immature myeloid cells (IMCs) might compromise the immune response to cancer. We studied in vivo circulating and splenic T lymphocyte and IMC subsets in patients with benign and malignant pancreatic diseases. We ascertained in vitro whether pancreatic adenoc...

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Main Authors: Basso, Daniela, Fogar, Paola, Falconi, Massimo, Fadi, Elisa, Sperti, Cosimo, Frasson, Chiara, Greco, Eliana, Tamburrino, Domenico, Teolato, Sara, Moz, Stefania, Bozzato, Dania, Pelloso, Michela, Padoan, Andrea, De Franchis, Giuseppe, Gnatta, Elisa, Facco, Monica, Zambon, Carlo-Federico, Navaglia, Filippo, Pasquali, Claudio, Basso, Giuseppe, Semenzato, Gianpietro, Pedrazzoli, Sergio, Pederzoli, Paolo, Plebani, Mario
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554636/
https://ncbi.nlm.nih.gov/pubmed/23359812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054824
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