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Positional Bias of MHC Class I Restricted T-Cell Epitopes in Viral Antigens Is Likely due to a Bias in Conservation

The immune system rapidly responds to intracellular infections by detecting MHC class I restricted T-cell epitopes presented on infected cells. It was originally thought that viral peptides are liberated during constitutive protein turnover, but this conflicts with the observation that viral epitope...

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Bibliografiske detaljer
Main Authors: Kim, Yohan, Yewdell, Jonathan W., Sette, Alessandro, Peters, Bjoern
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554532/
https://ncbi.nlm.nih.gov/pubmed/23357871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002884
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