Nonviral-Mediated Hepatic Expression of IGF-I Increases Treg Levels and Suppresses Autoimmune Diabetes in Mice

In type 1 diabetes, loss of tolerance to β-cell antigens results in T-cell–dependent autoimmune destruction of β cells. The abrogation of autoreactive T-cell responses is a prerequisite to achieve long-lasting correction of the disease. The liver has unique immunomodulatory properties and hepatic ge...

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Main Authors: Anguela, Xavier M., Tafuro, Sabrina, Roca, Carles, Callejas, David, Agudo, Judith, Obach, Mercè, Ribera, Albert, Ruzo, Albert, Mann, Christopher J., Casellas, Alba, Bosch, Fatima
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2013
Fag:
Immunology and Transplantation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554392/
https://ncbi.nlm.nih.gov/pubmed/23099863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1776
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