AAV8-mediated Sirt1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is the most common hepatic disease worldwide, and evidence suggests that it promotes insulin resistance and type 2 diabetes. Caloric restriction (CR) is the only available strategy for NAFLD treatment. The protein deacetylase Sirtuin1 (SIRT1), which is activa...

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Published in:Mol Ther Methods Clin Dev
Main Authors: Vilà, Laia, Elias, Ivet, Roca, Carles, Ribera, Albert, Ferré, Tura, Casellas, Alba, Lage, Ricardo, Franckhauser, Sylvie, Bosch, Fatima
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362360/
https://ncbi.nlm.nih.gov/pubmed/26015978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2014.39
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