Apolipoprotein E2 Accentuates Postprandial Inflammation and Diet-Induced Obesity to Promote Hyperinsulinemia in Mice

Genetic studies have revealed the association between the ε2 allele of the apolipoprotein E (apoE) gene and greater risk of metabolic diseases. This study compared C57BL/6 mice in which the endogenous mouse gene has been replaced by the human APOE2 or APOE3 gene (APOE2 and APOE3 mice) to identify th...

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Autores principales: Kuhel, David G., Konaniah, Eddy S., Basford, Joshua E., McVey, Courtney, Goodin, Colleen T., Chatterjee, Tapan K., Weintraub, Neal L., Hui, David Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2013
Materias:
Metabolism
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554349/
https://ncbi.nlm.nih.gov/pubmed/22961083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0390
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