Phosphorylation of Atg5 by the Gadd45β–MEKK4-p38 pathway inhibits autophagy

Autophagy is a lysosomal degradation pathway important for cellular homeostasis, mammalian development, cancer and immunity. Many molecular components of autophagy have been identified, but little is known about regulatory mechanisms controlling their effector functions. Here, we show that, in contr...

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Detalhes bibliográficos
Main Authors: Keil, E, Höcker, R, Schuster, M, Essmann, F, Ueffing, N, Hoffman, B, Liebermann, D A, Pfeffer, K, Schulze-Osthoff, K, Schmitz, I
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554344/
https://ncbi.nlm.nih.gov/pubmed/23059785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.129
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