Phosphorylation of Atg5 by the Gadd45β–MEKK4-p38 pathway inhibits autophagy

Autophagy is a lysosomal degradation pathway important for cellular homeostasis, mammalian development, cancer and immunity. Many molecular components of autophagy have been identified, but little is known about regulatory mechanisms controlling their effector functions. Here, we show that, in contr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Keil, E, Höcker, R, Schuster, M, Essmann, F, Ueffing, N, Hoffman, B, Liebermann, D A, Pfeffer, K, Schulze-Osthoff, K, Schmitz, I
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2013
Schlagworte:
Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554344/
https://ncbi.nlm.nih.gov/pubmed/23059785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.129
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