Antigenicity and Immunogenicity of RV144 Vaccine AIDSVAX Clade E Envelope Immunogen Is Enhanced by a gp120 N-Terminal Deletion

An immune correlates analysis of the RV144 HIV-1 vaccine trial revealed that antibody responses to the gp120 V1/V2 region correlated inversely with infection risk. The RV144 protein immunogens (A244-rp120 and MN-rgp120) were modified by an N-terminal 11-amino-acid deletion (Δ11) and addition of a he...

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Main Authors: Alam, S. Munir, Liao, Hua-Xin, Tomaras, Georgia D., Bonsignori, Mattia, Tsao, Chun-Yen, Hwang, Kwan-Ki, Chen, Haiyan, Lloyd, Krissey E., Bowman, Cindy, Sutherland, Laura, Jeffries, Thomas L., Kozink, Daniel M., Stewart, Shelley, Anasti, Kara, Jaeger, Frederick H., Parks, Robert, Yates, Nicole L., Overman, R. Glenn, Sinangil, Faruk, Berman, Phillip W., Pitisuttithum, Punnee, Kaewkungwal, Jaranit, Nitayaphan, Sorachai, Karasavva, Nicos, Rerks-Ngarm, Supachai, Kim, Jerome H., Michael, Nelson L., Zolla-Pazner, Susan, Santra, Sampa, Letvin, Norman L., Harrison, Stephen C., Haynes, Barton F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554162/
https://ncbi.nlm.nih.gov/pubmed/23175357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00718-12
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