Boosting with AIDSVAX B/E Enhances Env Constant Region 1 and 2 Antibody-Dependent Cellular Cytotoxicity Breadth and Potency

Induction of protective antibodies is a critical goal of HIV-1 vaccine development. One strategy is to induce nonneutralizing antibodies (NNAbs) that kill virus-infected cells, as these antibody specificities have been implicated in slowing HIV-1 disease progression and in protection. HIV-1 Env cons...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Easterhoff, David, Pollara, Justin, Luo, Kan, Tolbert, William D., Young, Brianna, Mielke, Dieter, Jha, Shalini, O’Connell, Robert J., Vasan, Sandhya, Kim, Jerome, Michael, Nelson L., Excler, Jean-Louis, Robb, Merlin L., Rerks-Ngarm, Supachai, Kaewkungwal, Jaranit, Pitisuttithum, Punnee, Nitayaphan, Sorachai, Sinangil, Faruk, Tartaglia, James, Phogat, Sanjay, Kepler, Thomas B., Alam, S. Munir, Wiehe, Kevin, Saunders, Kevin O., Montefiori, David C., Tomaras, Georgia D., Moody, M. Anthony, Pazgier, Marzena, Haynes, Barton F., Ferrari, Guido
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2020
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6997759/
https://ncbi.nlm.nih.gov/pubmed/31776278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01120-19
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