Pandemic 2009 H1N1 Influenza A Virus Carrying a Q136K Mutation in the Neuraminidase Gene Is Resistant to Zanamivir but Exhibits Reduced Fitness in the Guinea Pig Transmission Model

Resistance of influenza A viruses to neuraminidase inhibitors can arise through mutations in the neuraminidase (NA) gene. We show here that a Q136K mutation in the NA of the 2009 pandemic H1N1 virus confers a high degree of resistance to zanamivir. Resistance is accompanied by reduced numbers of NA...

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Hlavní autoři: Kaminski, Michael M., Ohnemus, Annette, Staeheli, Peter, Rubbenstroth, Dennis
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554154/
https://ncbi.nlm.nih.gov/pubmed/23192869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02507-12
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