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Proteolytic Processing of the Human Immunodeficiency Virus Envelope Glycoprotein Precursor Decreases Conformational Flexibility

The mature envelope glycoprotein (Env) spike on the surface of human immunodeficiency virus type 1 (HIV-1) virions is derived by proteolytic cleavage of a trimeric gp160 glycoprotein precursor. Remarkably, proteolytic processing of the HIV-1 Env precursor results in changes in Env antigenicity that...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Haim, Hillel, Salas, Ignacio, Sodroski, Joseph
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554131/
https://ncbi.nlm.nih.gov/pubmed/23175369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02765-12
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