Straightforward Selection of Broadly Neutralizing Single-Domain Antibodies Targeting the Conserved CD4 and Coreceptor Binding Sites of HIV-1 gp120

Few broadly neutralizing antibodies targeting determinants of the HIV-1 surface envelope glycoprotein (gp120) involved in sequential binding to host CD4 and chemokine receptors have been characterized. While these epitopes show low diversity among various isolates, HIV-1 employs many strategies to e...

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Autores principales: Matz, Julie, Kessler, Pascal, Bouchet, Jérôme, Combes, Olivier, Ramos, Oscar Henrique Pereira, Barin, Francis, Baty, Daniel, Martin, Loïc, Benichou, Serge, Chames, Patrick
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2013
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554102/
https://ncbi.nlm.nih.gov/pubmed/23152508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00461-12
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