Unusual sequence effects on nucleotide excision repair of arylamine lesions: DNA bending/distortion as a primary recognition factor

The environmental arylamine mutagens are implicated in the etiology of various sporadic human cancers. Arylamine-modified dG lesions were studied in two fully paired 11-mer duplexes with a -G*CN- sequence context, in which G* is a C8-substituted dG adduct derived from fluorinated analogs of 4-aminob...

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Autors principals: Jain, Vipin, Hilton, Benjamin, Lin, Bin, Patnaik, Satyakam, Liang, Fengting, Darian, Eva, Zou, Yue, MacKerell, Alexander D., Cho, Bongsup P.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2013
Matèries:
Genome Integrity, Repair and Replication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553991/
https://ncbi.nlm.nih.gov/pubmed/23180767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1077
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