SMG5–PNRC2 is functionally dominant compared with SMG5–SMG7 in mammalian nonsense-mediated mRNA decay

In mammals, nonsense-mediated mRNA decay (NMD) functions in post-transcriptional gene regulation as well as mRNA surveillance. A key NMD factor, Upf1, becomes hyperphosphorylated by SMG1 kinase during the recognition of NMD substrates. Hyperphosphorylated Upf1 interacts with several factors includin...

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Hlavní autoři: Cho, Hana, Han, Sisu, Choe, Junho, Park, Seung Gu, Choi, Sun Shim, Kim, Yoon Ki
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
RNA
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553988/
https://ncbi.nlm.nih.gov/pubmed/23234702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1222
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