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Eroded human telomeres are more prone to remain uncapped and to trigger a G2 checkpoint response
Telomeres cap the ends of chromosomes and regulate the replicative life span of human somatic cells. Telomere function is lost upon critical shortening and a p53-dependent checkpoint that detects altered telomere states at the G1/S transition was proposed to act as a regulator of the telomere damage...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3553962/ https://ncbi.nlm.nih.gov/pubmed/23193277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1121 |
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