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Eroded human telomeres are more prone to remain uncapped and to trigger a G2 checkpoint response

Telomeres cap the ends of chromosomes and regulate the replicative life span of human somatic cells. Telomere function is lost upon critical shortening and a p53-dependent checkpoint that detects altered telomere states at the G1/S transition was proposed to act as a regulator of the telomere damage...

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Detalhes bibliográficos
Main Authors: Jullien, Laurent, Mestre, Marie, Roux, Pierre, Gire, Véronique
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553962/
https://ncbi.nlm.nih.gov/pubmed/23193277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1121
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