7,8-dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases

Hydroxyl radicals predominantly react with the C(8) of purines forming 7,8-dihydro-8-oxoguanine (8oxoG) and 7,8-dihydro-8-oxoadenine (8oxoA) adducts, which are highly mutagenic in mammalian cells. The majority of oxidized DNA bases are removed by DNA glycosylases in the base excision repair pathway....

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Detalles Bibliográficos
Main Authors: Talhaoui, Ibtissam, Couvé, Sophie, Ishchenko, Alexander A., Kunz, Christophe, Schär, Primo, Saparbaev, Murat
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2013
Assuntos:
Genome Integrity, Repair and Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553953/
https://ncbi.nlm.nih.gov/pubmed/23209024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1149
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