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Ion-dependent conformational switching by a DNA aptamer that induces remyelination in a mouse model of multiple sclerosis

We recently reported that a guanosine-rich 40-mer DNA aptamer (LJM-3064) mediates remyelination in the Theiler’s murine encephalomyelitis virus mouse model of multiple sclerosis. Here, we characterize the G-quadruplex forms of this aptamer in vitro, and demonstrate using circular dichroism spectrosc...

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Detalhes bibliográficos
Main Authors: Smestad, John, Maher, L. James
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553947/
https://ncbi.nlm.nih.gov/pubmed/23175609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1093
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